Lipopolysaccharide: Biosynthetic pathway and structure modification.

  title={Lipopolysaccharide: Biosynthetic pathway and structure modification.},
  author={Xiaoyuan Wang and Peter J. Quinn},
  journal={Progress in lipid research},
  volume={49 2},
Lipopolysaccharide that constitutes the outer leaflet of the outer membrane of most Gram-negative bacteria is referred to as an endotoxin. It is comprised of a hydrophilic polysaccharide and a hydrophobic component referred to as lipid A. Lipid A is responsible for the major bioactivity of endotoxin, and is recognized by immune cells as a pathogen-associated molecule. Most enzymes and genes coding for proteins responsible for the biosynthesis and export of lipopolysaccharide in Escherichia coli… CONTINUE READING
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