Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson’s Disease

@article{Chen2016LipopolyplexFT,
  title={Lipopolyplex for Therapeutic Gene Delivery and Its Application for the Treatment of Parkinson’s Disease},
  author={Wei Chen and Hui Li and Zhenguo Liu and Weien Yuan},
  journal={Frontiers in aging neuroscience},
  year={2016},
  volume={8},
  pages={
          68
        }
}
Lipopolyplex is a core-shell structure composed of nucleic acid, polycation and lipid. As a non-viral gene delivery vector, lipopolyplex combining the advantages of polyplex and lipoplex has shown superior colloidal stability, reduced cytotoxicity, extremely high gene transfection efficiency. Following intravenous administration, there are many strategies based on lipopolyplex to overcome the complex biological barriers in systemic gene delivery including condensation of nucleic acids into… CONTINUE READING

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