Lipoplex size is a major determinant of in vitro lipofection efficiency

  title={Lipoplex size is a major determinant of in vitro lipofection efficiency},
  author={Pete Ross and Sek Wen Hui},
  journal={Gene Therapy},
The inhibition effect of serum on the transfection efficiency of cationic liposome–DNA complexes (lipoplexes) is a major obstacle to the application of this gene delivery vector both in vitro and in vivo. The size of the lipoplexes, as they are presented to targeted cells, is found to be the major determinant of their effectiveness in transfection. The transfection efficiency and the cell association and uptake of lipoplexes with CHO cells was found to increase with increasing lipoplex size… CONTINUE READING
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