Lipophilicity parameter from high-performance liquid chromatography on an immobilized artificial membrane column and its relationships to bioactivity of the group of 2,4-dihydroxythiobenzanilides.

Several groups of 2,4-dihydroxythiobenzanilide derivatives are extensively studied in our laboratories as potential antifungal or antibacterial agents. Previous papers showed that their biological activities are closely correlated with the lipophilicity determined in HPLC experiments using on octadecylsilyl stationary phase (RP-18). In the present paper we… CONTINUE READING