Lipophilicity determination of highly lipophilic compounds by liquid chromatography.

Abstract

Different experimental strategies using short columns in both conventional liquid chromatography (HPLC) and ultra-high pressure liquid chromatography (UHPLC) were evaluated to allow, for the first time with these techniques, the lipophilicity determination of compounds with log P>5. Various organic modifiers, stationary phases, and elution modes were tested… (More)
DOI: 10.1002/cbdv.200900115

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