Lipophilicity and Its Relationship with Passive Drug Permeation

@article{Liu2010LipophilicityAI,
  title={Lipophilicity and Its Relationship with Passive Drug Permeation},
  author={Xiangli Liu and Bernard Testa and Alfred Fahr},
  journal={Pharmaceutical Research},
  year={2010},
  volume={28},
  pages={962-977}
}
ABSTRACTIn this review, we first summarize the structure and properties of biological membranes and the routes of passive drug transfer through physiological barriers. Lipophilicity is then introduced in terms of the intermolecular interactions it encodes. Finally, lipophilicity indices from isotropic solvent systems and from anisotropic membrane-like systems are discussed for their capacity to predict passive drug permeation across biological membranes such as the intestinal epithelium, the… CONTINUE READING

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