Lipophilicity Behaviour of the Zwitterionic Antihistamine Cetirizine in Phosphatidylcholine Liposomes/Water Systems

@article{Balen2001LipophilicityBO,
  title={Lipophilicity Behaviour of the Zwitterionic Antihistamine Cetirizine in Phosphatidylcholine Liposomes/Water Systems},
  author={Georgette Plemper van Balen and Giulia Caron and Giuseppe Ermondi and Alessandra Pagliara and Teresa Grandi and G{\'e}raldine Bouchard and Roberta Fruttero and Pierre–Alain Carrupt and Bernard Testa},
  journal={Pharmaceutical Research},
  year={2001},
  volume={18},
  pages={694-701}
}
Purpose. The partitioning of cetirizine in a phosphatidylcholine liposomes/water system was compared with that of hydroxyzine and acrivastine to gain insight into the mechanisms of interaction of its various electrical species with membranes. Methods. The lipophilicity profiles of the compounds were obtained from equilibrium dialysis and potentiometry, and… CONTINUE READING