Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system

@article{Kornhuber2010LipophilicCD,
  title={Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system},
  author={Johannes Kornhuber and Andreas Wolfram Henkel and Teja Wolfgang Groemer and Sven St{\"a}dtler and Oliver Welzel and Philipp Tripal and Andrea Rotter and Stefan Bleich and Stefan Trapp},
  journal={Journal of Cellular Physiology},
  year={2010},
  volume={224}
}
Lysosomes accumulate many drugs several fold higher compared to their extracellular concentration. This mechanism is believed to be responsible for many pharmacological effects. So far, uptake and release kinetics are largely unknown and interactions between concomitantly administered drugs often provoke mutual interference. In this study, we addressed these questions in a cell culture model. The molecular mechanism for lysosomal uptake kinetics was analyzed by live cell fluorescence microscopy… 
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