Lipophilic &bgr;-Blockers and Suicide in the Elderly

  title={Lipophilic \&bgr;-Blockers and Suicide in the Elderly},
  author={Jonathan S. Zipursky and Erin M Macdonald and Jin Luo and Tara Gomes and Muhammad M Mamdani and J. Michael Paterson and David N Juurlink},
  journal={Journal of Clinical Psychopharmacology},
To the Editorsβ-Adrenergic blockers (β-blockers) are among the most widely prescribed drugs in the world, with more than 191 million prescriptions dispensed in the United States in 2010 alone.1 They are commonly used to manage hypertension, heart failure, and arrhythmias and for the secondary preven 
2 Citations

Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide

In this case-control study of older adults who died by suicide and matched control participants, compared with angiotensin-converting enzyme inhibitors, exposure to angiotENSin receptor blockers was associated with a higher risk of suicide.

Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States

In adjusted analyses excluding users of antidepressants, the number of medications used with depression as possible adverse effects was associated with increased prevalence of concurrent depression, and these patterns persisted in analyses restricted to adults treated with antidepressants, among hypertensive adults, and afterexcluding users of any psychotropic medication.



&bgr;-Blockers and the Risk of Incident Depression in the Elderly

It is found that use of &bgr;-blockers in general did not convey an increased risk of depressive symptoms and nonselective or serotonergic receptor affinity was not associated with an increasedrisk of depressive Symptoms or syndromes independent of high lipid solubility.

Propranolol-induced depression.

  • H. Waal
  • Medicine, Psychology
    British medical journal
  • 1967
Therapeutic indications for the betareceptor adrenergic blocking agent propranolol include angina, cardiac arrythmias, and hypertension, and there are reports of its value in phaeochromocytoma not amenable to surgery, hypertrophic obstructive cardiomyopathy, Parkinsonian tremor, and anxiety.

Propranolol and depression.

Physicians' awareness of this complication, especially in cases of patients with a history of depression, may reduce the occurrence of this drug reaction.

Risk of suicide in users of beta-adrenoceptor blockers, calcium channel blockers and angiotensin converting enzyme inhibitors.

Users of medium and high lipid soluble beta-adrenoceptor blockers may have an increased risk of suicide and users of calcium channel blockers and angiotensin converting enzyme inhibitors do not seem to have a significantly increasedrisk of suicide.

β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction

The conventional wisdom that β-blocker therapy is associated with substantial risks of depressive symptoms, fatigue, and sexual dysfunction is not supported by data from clinical trials.

β-blocker brain concentrations in man

The brain is buffered from peak blood concentrations of atenolol, and this may account for the low incidence of CNS-related side-effects with this hydrophilic β-blocker.

Propranolol and Depression: Evidence from the Antihypertensive Trials

  • S. Patten
  • Psychology, Medicine
    Canadian journal of psychiatry. Revue canadienne de psychiatrie
  • 1990
Re-analyzing side effect data from clinical trials of propranolol as an antihypertensive agent found it to cause depression as a side effect with a statistically greater frequency than the control medications used in these trials.

Propranolol and depression revisited: three cases and a review.

Three cases are reported of depressions meeting DSM-III criteria following administration of propranolol for medical conditions, and possible relationships between beta blockade and affective illness are discussed.