Lipolytic and adenyl-cyclase-stimulating activity of glucagon1–6: comparison with glucagon derivatives chemically modified in the 7–29 sequence

@article{JeanBaptiste1982LipolyticAA,
  title={Lipolytic and adenyl-cyclase-stimulating activity of glucagon1–6: comparison with glucagon derivatives chemically modified in the 7–29 sequence},
  author={Emile Jean-Baptiste and Martin A. Rizack and Richard M. Epand},
  journal={Bioscience Reports},
  year={1982},
  volume={2},
  pages={819-824}
}
  • Emile Jean-Baptiste, Martin A. Rizack, Richard M. Epand
  • Published 1982
  • Chemistry, Medicine
  • Bioscience Reports
  • Glucagon1–6 has a maximum lipolytic activity (Lmax) in the rat adipocyte which is 66% of that of glucagon. The Nε-guanidyl derivative, modified at Lys12 , has about the same Lmax as glucagon1–6. Modifying the carboxyl groups of glucagon with glycinamide or removing the COON-terminal residues with cyanogen bromide reduces Lmax to less than 25% of the level of glucagon. The potency of each of these analogs (A50) in μM is as follows: glucagon 6×10−3; glucagon1–6 2 ×10−2; Nε-guanidyl glucagon 9×10… CONTINUE READING