Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency.

@article{Mitropoulos1992LipolysisOT,
  title={Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency.},
  author={K A. Mitropoulos and George J. Miller and Gerald F. M. Watts and Paul N. Durrington},
  journal={Atherosclerosis},
  year={1992},
  volume={95 2-3},
  pages={119-25}
}
A high factor VII coagulant activity (VIIc), a marker of increased risk of coronary heart disease, is frequently found in types IIb and IV hyperlipidaemia, but its cause is not fully understood. Factor VII can be activated by factor XIIa, generated from factor XII upon activation of the contact system of coagulation. Ten patients with familial lipoprotein-lipase (LPL) deficiency and 10 healthy control subjects were therefore compared to explore the hypothesis that high concentrations of… CONTINUE READING

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