Lipoic acid synthesis and attachment in yeast mitochondria.

@article{Schonauer2009LipoicAS,
  title={Lipoic acid synthesis and attachment in yeast mitochondria.},
  author={Melissa S Schonauer and Alexander J Kastaniotis and V. A. Samuli Kursu and J Kalervo Hiltunen and Carol Dieckmann},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 35},
  pages={23234-42}
}
Lipoic acid is a sulfur-containing cofactor required for the function of several multienzyme complexes involved in the oxidative decarboxylation of alpha-keto acids and glycine. Mechanistic details of lipoic acid metabolism are unclear in eukaryotes, despite two well defined pathways for synthesis and covalent attachment of lipoic acid in prokaryotes. We report here the involvement of four genes in the synthesis and attachment of lipoic acid in Saccharomyces cerevisiae. LIP2 and LIP5 are… CONTINUE READING

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