Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.

@article{Rezk2004LipoicAP,
  title={Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.},
  author={Bashir M. Rezk and Guido R M M Haenen and W J Van der vijgh and Aalt Bast},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 11},
  pages={9693-7}
}
The ability of the sulfur-containing compounds glutathione (GSH), glutathione disulphide (GSSG), S-methylglutathione (GSMe), lipoic acid (LA), and dihydrolipoic acid (DHLA) to protect against hypochlorous acid (HOCl)-mediated damage and peroxynitrite (ONOOH)-induced damage has been compared. Protective activity was assessed in competition assays by monitoring several detectors, i.e. dihydrorhodamine-123 (DHR-123) oxidation, alpha(1)-antiproteinase (alpha(1)-AP) inactivation, and glutathione S… CONTINUE READING