Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet.

@article{Xiao2011LipoicAI,
  title={Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet.},
  author={Ying Xiao and Jue Cui and Yonghui Shi and Guowei Le},
  journal={Nutrition research},
  year={2011},
  volume={31 4},
  pages={309-17}
}
Antioxidant lipoic acid (LA) has been reported to have a potential prophylactic effect on bone loss induced by high-fat diet (HFD). The aim of this work was to examine the hypothesis that LA decreases bone resorption-related gene expression and increases bone formation-related gene expression in HFD-fed mice, preventing a shift in the bone metabolism balance toward resorption. Male C57BL/6 mice were fed a normal diet, HFD, or HFD plus 0.1% LA for 12 weeks. The bone metabolism-related genes… CONTINUE READING

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Antioxidant lipoic acid ( LA ) has been reported to have a potential prophylactic effect on bone loss induced by high - fat diet ( HFD ) .
Lipoic acid induced upregulation of Il12a ( 2.1-fold ) and downregulation of Tgfbr1 ( 4.3-fold ) and Il17a ( 11.3-fold ) , which may reduce bone resorption .
Lipoic acid induced upregulation of Il12a ( 2.1-fold ) and downregulation of Tgfbr1 ( 4.3-fold ) and Il17a ( 11.3-fold ) , which may reduce bone resorption .
Lipoic acid induced upregulation of Il12a ( 2.1-fold ) and downregulation of Tgfbr1 ( 4.3-fold ) and Il17a ( 11.3-fold ) , which may reduce bone resorption .
Antioxidant lipoic acid ( LA ) has been reported to have a potential prophylactic effect on bone loss induced by high - fat diet ( HFD ) .
Lipoic acid induced upregulation of Il12a ( 2.1-fold ) and downregulation of Tgfbr1 ( 4.3-fold ) and Il17a ( 11.3-fold ) , which may reduce bone resorption .
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