Lipoic acid - biological activity and therapeutic potential.

  title={Lipoic acid - biological activity and therapeutic potential.},
  author={Anna Gorąca and Halina Huk-Kolega and Aleksandra Piechota and Paulina Kleniewska and Elzbieta B Ciejka and Beata Skibska},
  journal={Pharmacological reports : PR},
  volume={63 4},
α-Lipoic acid (LA; 5-(1,2-dithiolan-3-yl)pentanoic acid) was originally isolated from bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was found that LA is not a vitamin and is synthesized by plants and animals. LA is covalently bound to the ε-amino group of lysine residues and functions as a cofactor for mitochondrial enzymes by catalyzing the oxidative decarboxylation of pyruvate, α-ketoglutarate and branched-chain α-keto acids. LA and its reduced form… CONTINUE READING
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