Lipoglycans are putative ligands for the human pulmonary surfactant protein A attachment to mycobacteria. Critical role of the lipids for lectin-carbohydrate recognition.

@article{Sidobre2000LipoglycansAP,
  title={Lipoglycans are putative ligands for the human pulmonary surfactant protein A attachment to mycobacteria. Critical role of the lipids for lectin-carbohydrate recognition.},
  author={St{\'e}phane Sidobre and J{\'e}r{\^o}me Nigou and Germain Puzo and Michel Riviere},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 4},
  pages={
          2415-22
        }
}
The human pulmonary surfactant protein A (hSP-A) has been implicated in the early capture and phagocytosis of the pathogenic Mycobacterium tuberculosis by alveolar macrophages. In this report, we examined the interaction of alveolar proteinosis patient hSP-A with Mycobacterium bovis BCG, the vaccinating strain, as a model of pathogenic mycobacteria, and Mycobacterium smegmatis, a nonpathogenic strain. We found that hSP-A binds to the surface of M. bovis BCG, but also to a slightly lesser extent… CONTINUE READING

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Pulmonary Collectin A Bind to Mycobacterial Lipoglycans

  • W. I. Weis, K. Drickamer
  • Annu. Rev. Biochem
  • 1996
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