Lipoglycans Contribute to Innate Immune Detection of Mycobacteria

  title={Lipoglycans Contribute to Innate Immune Detection of Mycobacteria},
  author={S. Sai Krishna and Aur{\'e}lie Ray and Shiv Kumar Dubey and Gerald Larrouy-Maumus and Christian Chalut and Romain Castanier and Audrey Noguera and Martine Gilleron and Germain Puzo and Alain Vercellone and Kesavan Madhavan Nampoothiri and J{\'e}r{\^o}me Nigou},
  booktitle={PloS one},
Innate immune recognition is based on the detection, by pattern recognition receptors (PRRs), of molecular structures that are unique to microorganisms. Lipoglycans are macromolecules specific to the cell envelope of mycobacteria and related genera. They have been described to be ligands, as purified molecules, of several PRRs, including the C-type lectins Mannose Receptor and DC-SIGN, as well as TLR2. However, whether they are really sensed by these receptors in the context of a bacterium… CONTINUE READING
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