Lipoglycans Contribute to Innate Immune Detection of Mycobacteria

@article{Krishna2011LipoglycansCT,
  title={Lipoglycans Contribute to Innate Immune Detection of Mycobacteria},
  author={Shyam Krishna and Aur{\'e}lie Ray and S. K. Dubey and G. Larrouy-Maumus and C. Chalut and R. Castanier and A. Noguera and M. Gilleron and G. Puzo and Alain Vercellone and K. Nampoothiri and J. Nigou},
  journal={PLoS ONE},
  year={2011},
  volume={6}
}
  • Shyam Krishna, Aurélie Ray, +9 authors J. Nigou
  • Published 2011
  • Medicine, Biology
  • PLoS ONE
  • Innate immune recognition is based on the detection, by pattern recognition receptors (PRRs), of molecular structures that are unique to microorganisms. Lipoglycans are macromolecules specific to the cell envelope of mycobacteria and related genera. They have been described to be ligands, as purified molecules, of several PRRs, including the C-type lectins Mannose Receptor and DC-SIGN, as well as TLR2. However, whether they are really sensed by these receptors in the context of a bacterium… CONTINUE READING

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 47 REFERENCES
    Lipoarabinomannans: from structure to biosynthesis.
    252
    TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity.
    338
    Mannan Chain Length Controls Lipoglycans Signaling via and Binding to TLR21
    68
    Lipoteichoic Acid in Streptomyces hygroscopicus: Structural Model and Immunomodulatory Activities
    16