Lipofuscin in the retina: quantitative assay for an unprecedented autofluorescent compound (pyridinium bis-retinoid, A2-E) of ocular age pigment.

@article{Reinboth1997LipofuscinIT,
  title={Lipofuscin in the retina: quantitative assay for an unprecedented autofluorescent compound (pyridinium bis-retinoid, A2-E) of ocular age pigment.},
  author={J{\"o}rg Reinboth and K. Gautschi and Kurt Munz and Graig E. Eldred and Charlotte E. Rem{\'e}},
  journal={Experimental eye research},
  year={1997},
  volume={65 5},
  pages={639-43}
}
The pyridinium bis-retinoid, A2-E, has been discovered as one of the major autofluorescent components of retinal pigment epithelial lipofuscin. Due to its chemical characteristics, A2-E may contribute to cellular and molecular changes leading to age-related macular degeneration. Because A2-E is the first lipofuscin component that has been identified, purified, and its structure analysed, it represents an important marker molecule for studying lipofuscin formation under various conditions. In… CONTINUE READING

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