Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration.

@article{Eldred1995LipofuscinFI,
  title={Lipofuscin fluorophore inhibits lysosomal protein degradation and may cause early stages of macular degeneration.},
  author={Graig E. Eldred},
  journal={Gerontology},
  year={1995},
  volume={41 Suppl 2},
  pages={15-28}
}
One of the autofluorescent compounds that accumulates within the lipofuscin granules of the human retinal pigment epithelium (RPE) has now been identified as a quaternary nitrogen-containing cationic amphiphile (the bis-retinoid pyridinium salt, A2-E). Experimental evidence suggests that it may be responsible for lipofuscinogenesis in the RPE through its ability to inhibit lysosomal proteolysis. Furthermore, it may be involved in the events that trigger the changes leading to age-related… CONTINUE READING

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