Lipofuscin: mechanisms of age-related accumulation and influence on cell function.

@article{Brunk2002LipofuscinMO,
  title={Lipofuscin: mechanisms of age-related accumulation and influence on cell function.},
  author={U. Brunk and A. Terman},
  journal={Free radical biology \& medicine},
  year={2002},
  volume={33 5},
  pages={
          611-9
        }
}
  • U. Brunk, A. Terman
  • Published 2002
  • Biology, Chemistry, Medicine
  • Free radical biology & medicine
The accumulation of lipofuscin within postmitotic cells is a recognized hallmark of aging occurring with a rate inversely related to longevity. Lipofuscin is an intralysosomal, polymeric substance, primarily composed of cross-linked protein residues, formed due to iron-catalyzed oxidative processes. Because it is undegradable and cannot be removed via exocytosis, lipofuscin accumulation in postmitotic cells is inevitable, whereas proliferative cells efficiently dilute it during division. The… Expand
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Lipofuscin is a membrane-bound cellular waste that can be neither degraded nor ejected from the cell but can only be diluted through cell division and subsequent growth. The fate of postmitoticExpand
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This review highlights the current knowledge of the formation, distribution, and effects of lipofuscin in mammalian cells and investigates the role of mitochondria repair systems and the functionality and effectiveness of the lysosomes. Expand
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Disturbed apoptotic response found in lipofuscin-loaded cells can be interpreted as an example of hormesis—an adaptation to low doses of otherwise harmful agents, in this case of lip ofuscin, which has a protective effect at moderate amounts but becomes toxic at large quantities. Expand
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  • Biology, Medicine
  • Science of aging knowledge environment : SAGE KE
  • 2005
TLDR
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The current findings demonstrate that free radical-mediated modifications to protein that lead to the production of inhibitor(s) of cellular proteolytic systems are present on specific protein components of lipofuscin. Expand
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  • I. Perrotta
  • Chemistry, Medicine
  • Ultrastructural pathology
  • 2018
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The present study investigates the occurrence and distribution of lipofuscin and ceroid in human atherosclerotic plaque and adjacent healthy tissues and analyzes the ultrastructural changes associated with their accumulation within the cell. Expand
Can lipofuscin accumulation be prevented?
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  • Chemistry, Medicine
  • Rejuvenation research
  • 2008
TLDR
It is suggested that pulse doses of iron chelators that easily penetrate membranes could be used to diminish lipofuscinogenesis. Expand
Mitochondrial Autophagy and Lipofuscin Accumulation in Aging Odontoblasts
TLDR
Age-related changes in odontoblasts are observed as a long-term process in which the progressive accumulation of intralysosomal debris limits the autophagic turnover of mitochondrial components, causing an eventual decline in physiological cell functions, which leads to increased vulnerability under stress conditions. Expand
Lysosome-targeted stress reveals increased stability of lipofuscin-containing lysosomes
TLDR
It is suggested that lipofuscin exerts lysosome-stabilizing properties and was less affected or even preserved in case of lip ofuscin-loaded cells. Expand
Role of macrophages in age-related oxidative stress and lipofuscin accumulation in mice
TLDR
It is shown that macrophages play a central role in the chronic oxidative stress associated with aging, and the fact that phagocytes are key cells contributing to immunosenescence and “oxi-inflamm-aging” is supported. Expand
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
Lipofuscin has the capacity to reduce the efficacy of the lysosomal and antioxidant systems in RPE cells that may play an important role in retinal ageing and the development of age-related macular degeneration. Expand
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