Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation.

@article{Herouy1998LipodermatosclerosisIC,
  title={Lipodermatosclerosis is characterized by elevated expression and activation of matrix metalloproteinases: implications for venous ulcer formation.},
  author={Yared Herouy and Ahmed El May and G Pornschlegel and Christoph Stetter and Harald Grenz and Klaus Theo Preissner and Erwin Sch{\"o}pf and Johannes Norgauer and Wolfgang Vanscheidt},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 5},
  pages={822-7}
}
Lipodermatosclerosis refers to skin induration of the lower extremities and is associated with patients preceding venous ulcerations. To better understand the pathogenesis of ulcer formation we investigated the expression of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) in lipodermatosclerosis. By preparing biopsies from healthy skin and liposclerotic lesions, MMP-1, MMP-2, MMP-9, TIMP-1, and TIMP-2 were analyzed by using reverse transcriptase-polymerase… CONTINUE READING