Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis.

@article{Lin2016Lipocalin2P,
  title={Lipocalin 2 prevents oral cancer metastasis through carbonic anhydrase IX inhibition and is associated with favourable prognosis.},
  author={Chiao-Wen Lin and Wei-En Yang and Wei-Jiunn Lee and Kuo-Tai Hua and Feng-Koo Hsieh and Michael Hsiao and Chia-Cheng Chen and J F Chow and M K Chen and Shun-Fa Yang and Ming-Hsien Chien},
  journal={Carcinogenesis},
  year={2016},
  volume={37 7},
  pages={712-722}
}
Lipocalin 2 (LCN2), a secreted glycoprotein, is up- or downregulated in different human cancers. At present, the functional role of LCN2 in the progression of oral squamous cell carcinoma (OSCC), which accounts for most head and neck cancers, remains poorly understood, particularly with respect to its involvement in invasion and metastasis. In this study, we observed that LCN2 expression decreased in patients with OSCC and lymph node metastasis compared with that in patients without metastasis… CONTINUE READING
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