Lipocalin-2-induced renal regeneration depends on cytokines.

  title={Lipocalin-2-induced renal regeneration depends on cytokines.},
  author={Eugenia Vinuesa and Anna Sola and Michaela Jung and Vicente Alfaro and Georgina Hotter},
  journal={American journal of physiology. Renal physiology},
  volume={295 5},
This study investigated whether the renal regeneration occurring in the recovery phase of kidney ischemia-reperfusion (I/R) is mediated by endogenously generated lipocalin-2 (Lcn2). A second objective was to examine whether Lcn2-mediated cell effects could be regulated by the inflammatory cytokines in the environment through their action on Lcn2 receptors (Lcn2R and megalin). Male Swiss mice were subjected to 30 min of renal ischemia with a reperfusion period of 24 h (early reperfusion… CONTINUE READING