Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice.

@article{Tarin2016Lipocalin2DO,
  title={Lipocalin-2 deficiency or blockade protects against aortic abdominal aneurysm development in mice.},
  author={Carlos A. Tarin and Carlos Ernesto Fernandez-Garcia and Elena Burillo and Carlos Pastor-Vargas and Patricia Llamas-Granda and Borja Castej{\'o}n and Priscila Ramos-Mozo and Monica Maria Torres-Fonseca and Thorsten Berger and Tak W Mak and Jes{\'u}s Egido and Lu{\'i}s Miguel Blanco-Colio and Jos{\'e}-Luis Martin-Ventura},
  journal={Cardiovascular research},
  year={2016},
  volume={111 3},
  pages={
          262-73
        }
}
AIMS To study the role of lipocalin-2 (Lcn2) and the effect of Lcn2 blockade via anti-Lcn2 antibody in the development of abdominal aortic aneurysm (AAA). METHODS AND RESULTS Expression mRNA and protein levels of Lcn2 and its human orthologue neutrophil gelatinase-associated lipocalin (NGAL) in aortic wall samples from experimental mouse and human AAA samples, respectively, were analysed by real-time PCR and immunohistochemistry. Experimental AAA was induced by aortic elastase perfusion in… CONTINUE READING
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