Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.

@article{Warszawska2013Lipocalin2D,
  title={Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes.},
  author={Joanna Maria Warszawska and Riem Gawish and Omar Sharif and Stefanie Sigel and Bianca Doninger and Karin Lakovits and Ildiko Mesteri and Manfred Nairz and Louis Boon and Alexander Spiel and Valentin Fuhrmann and Birgit Strobl and Mathias M{\"u}ller and Peter Schenk and Guenter Weiss and Sylvia Knapp},
  journal={The Journal of clinical investigation},
  year={2013},
  volume={123 8},
  pages={
          3363-72
        }
}
Macrophages play a key role in responding to pathogens and initiate an inflammatory response to combat microbe multiplication. Deactivation of macrophages facilitates resolution of the inflammatory response. Deactivated macrophages are characterized by an immunosuppressive phenotype, but the lack of unique markers that can reliably identify these cells explains the poorly defined biological role of this macrophage subset. We identified lipocalin 2 (LCN2) as both a marker of deactivated… CONTINUE READING
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