Lipoarabinomannans: characterization of the multiacylated forms of the phosphatidyl-myo-inositol anchor by NMR spectroscopy.

@article{Nigou1999LipoarabinomannansCO,
  title={Lipoarabinomannans: characterization of the multiacylated forms of the phosphatidyl-myo-inositol anchor by NMR spectroscopy.},
  author={J{\'e}r{\^o}me Nigou and Martine Gilleron and Germain Puzo},
  journal={The Biochemical journal},
  year={1999},
  volume={337 ( Pt 3)},
  pages={
          453-60
        }
}
Lipoarabinomannans, which exhibit a large spectrum of immunological activities, emerge as the major antigens of mycobacterial envelopes. The lipoarabinomannan structure is based on a phosphatidyl-myo-inositol anchor whose integrity has been shown to be crucial for lipoarabinomannan biological activity and particularly for presentation to CD4/CD8 double-negative alphabetaT cells by CD1 molecules. In this report, an analytical approach was developed for high-resolution 31P-NMR analysis of native… CONTINUE READING
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