Lipo-oligosaccharides (LOS) of mucosal pathogens: molecular mimicry and host-modification of LOS.

  title={Lipo-oligosaccharides (LOS) of mucosal pathogens: molecular mimicry and host-modification of LOS.},
  author={Robert E. Mandrell and Michael A. Apicella},
  volume={187 3-5},
Immunochemical studies of the lipo-oligosaccharides (LOS) of the Gram-negative bacteria Neisseria gonorrhoeae and Neisseria meningitidis have revealed some interesting structural characteristics of these LOS that might relate to their roles during pathogenesis. The carbohydrate moieties of the LOS of pathogenic Neisseria mimic carbohydrates present in glycosphingolipids of human cells. Firstly, an LOS component present among a number of Neisseria species is antigenically and/or chemically… CONTINUE READING


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