Lipin 2 Is a Liver-enriched Phosphatidate Phosphohydrolase Enzyme That Is Dynamically Regulated by Fasting and Obesity in Mice*

@article{Gropler2009Lipin2I,
  title={Lipin 2 Is a Liver-enriched Phosphatidate Phosphohydrolase Enzyme That Is Dynamically Regulated by Fasting and Obesity in Mice*},
  author={Matthew C. Gropler and T. Harris and A. M. Hall and N. Wolins and R. Gross and Xianlin Han and Z. Chen and B. Finck},
  journal={Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={6763 - 6772}
}
Lipin 1 is a bifunctional intracellular protein that regulates fatty acid metabolism in the nucleus via interactions with DNA-bound transcription factors and at the endoplasmic reticulum as a phosphatidic acid phosphohydrolase enzyme (PAP-1) to catalyze the penultimate step in triglyceride synthesis. However, livers of 8-day-old mice lacking lipin 1 (fld mice) exhibited normal PAP-1 activity and a 20-fold increase in triglyceride levels. We sought to further analyze the hepatic lipid profile of… Expand
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  • K. Reue
  • Biology, Medicine
  • Current opinion in lipidology
  • 2009
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References

SHOWING 1-10 OF 31 REFERENCES
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
...
1
2
3
4
...