Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

Abstract

Perturbations in hepatic lipid homeostasis are linked to the development of obesity-related steatohepatitis. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. However, the molecular function of lipin 1 is unclear. Herein, we demonstrate that the expression of lipin 1 is induced by peroxisome… (More)

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@article{Finck2006Lipin1I, title={Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.}, author={Brian N Finck and Matthew C. Gropler and Zhouji Chen and Teresa C. Leone and Michelle A. Croce and Thurl E. Harris and John C. Lawrence and Daniel P. Kelly}, journal={Cell metabolism}, year={2006}, volume={4 3}, pages={199-210} }