Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway

@article{Finck2006Lipin1I,
  title={Lipin 1 is an inducible amplifier of the hepatic PGC-1$\alpha$/PPAR$\alpha$ regulatory pathway},
  author={B. Finck and Matthew C. Gropler and Z. Chen and T. Leone and Michelle A. Croce and T. Harris and J. Lawrence and D. Kelly},
  journal={Cell Metabolism},
  year={2006},
  volume={4},
  pages={199-210}
}
Perturbations in hepatic lipid homeostasis are linked to the development of obesity-related steatohepatitis. Mutations in the gene encoding lipin 1 cause hepatic steatosis in fld mice, a genetic model of lipodystrophy. However, the molecular function of lipin 1 is unclear. Herein, we demonstrate that the expression of lipin 1 is induced by peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha (PGC-1alpha), a transcriptional coactivator controlling several key hepatic… Expand
[Lipin 1 in lipid metabolism].
  • K. Ishimoto
  • Chemistry, Medicine
  • Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
  • 2011
PGC-1α negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erbα axis
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