Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.

  title={Lipin-1γ isoform is a novel lipid droplet-associated protein highly expressed in the brain.},
  author={Huajin Wang and Jing Zhang and Wei Qiu and Gil-Soo Han and George M Carman and Khosrow Adeli},
  journal={FEBS letters},
  volume={585 12},
Lipin-1 proteins are phosphatidic acid phosphatases (PAPs) catalyzing the conversion from phosphatidic acid (PA) to diacylglycerol (DG). Two alternative splicing isoforms, lipin-1α and -1β, are localized at different subcellular compartments. A third splicing isoform, lipin-1γ was recently cloned and its subcellular localization is unknown. Here, we demonstrate that lipin-1γ is localized to lipid droplets (LDs), an association mediated by a hydrophobic, lipin-1γ-specific domain. Additional… CONTINUE READING
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