Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.

@article{Lenzi1996LipidsOT,
  title={Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy.},
  author={Andrea Lenzi and Mauro Picardo and Loredana Gandini and Franco Dondero},
  journal={Human reproduction update},
  year={1996},
  volume={2 3},
  pages={
          246-56
        }
}
This article is, in part, a review of present knowledge regarding the lipid metabolism of the sperm cell and the lipid composition of the sperm plasma membrane. It is also a summary of our research on this topic, reporting published and unpublished data. The article tries to cover both basic and clinical research. Sperm cells use lipid metabolic pathways for the production of part of their energy. The double leaflets of the membrane are not simply a passive, bilayer, lipidic film in which the… 

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References

SHOWING 1-10 OF 60 REFERENCES
Lipid composition and metabolism in testicular and ejaculated ram spermatozoa.
TLDR
It is suggested that lipids are a source of substrate for spermatozoa during their passage through the epididymis as well as radioactivity from glucose into formate than into acetate, whereas a higher proportion of radioactivity was found in acetate in ejaculated cells.
Correlation between changes in rat sperm membrane lipids, protein, and the membrane physical state during epididymal maturation.
TLDR
The data suggest that the apparent fluidity and biochemical composition of the sperm membrane change during epididymal maturation.
Glutathione treatment of dyspermia: effect on the lipoperoxidation process.
TLDR
It is suggested that biochemical modifications in membrane constitution could explain the seminal results of glutathione therapy and only subjects with systemic membrane disturbances associated with andrological pathologies express this membrane damage in spermatozoa, resulting in dyspermia.
Effects of various lipids on the acrosome reaction and fertilizing capacity of guinea pig spermatozoa with special reference to the possible involvement of lysophospholipids in the acrosome reaction
TLDR
It is suggested that lysophospholipids are intricately involved in the sperm acrosome reaction and perhaps in sperm-egg fusion.
Reactive Oxygen Species and Human Sperm Function
The human spermatozoon is a slightly differentiated cell which has developed a distinctly compartmentalised structure in order to accommodate the variety of diverse biological functions required to
Generation of reactive oxygen species, lipid peroxidation, and human sperm function.
TLDR
Results are consistent with a causative role for lipid peroxidation in the etiology of defective sperm function and also suggest a possible physiological role for the reactive oxygen species generated by human spermatozoa in mediating sperm-zona interaction.
Effects of antioxidants on human sperm preparation techniques.
TLDR
The results indicate that Percoll gradient centrifugation selects spermatozoa with better functional competence than does centrifugion swim-up, suggesting that the differences noted with the Per Coll gradient method was due to better protection against peroxidative damage due to the centrifugations of unselected spermatozosa.
The phospholipid composition of human spermatozoa and seminal plasma.
The phospholipid composition of human spermatozoa and seminal plasma was examined by quantitative 2-dimensional thin-layer chromatography followed by phosphorus analysis. The pattern was compared
Role of glutathione peroxidase in protecting mammalian spermatozoa from loss of motility caused by spontaneous lipid peroxidation.
TLDR
A mechanism for spontaneous lipid peroxidation in mammalian sperm is postulated which involves reaction of lipid hydroperoxide and O2 as the rate-determining step and the key intermediate is lipid hydro peroxide generated by a chain reaction initiated by and utilizing superoxide.
...
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