Lipids and topological rules of membrane protein assembly: balance between long and short range lipid-protein interactions.


The N-terminal six-transmembrane domain (TM) bundle of lactose permease of Escherichia coli is uniformly inverted when assembled in membranes lacking phosphatidylethanolamine (PE). Inversion is dependent on the net charge of cytoplasmically exposed protein domains containing positive and negative residues, net charge of the membrane surface, and low… (More)
DOI: 10.1074/jbc.M110.214387


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