Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase

@inproceedings{Jiang2017LipidsAI,
  title={Lipids and ions traverse the membrane by the same physical pathway in the nhTMEM16 scramblase},
  author={Tao Jiang and Kuai Yu and H Criss Hartzell and Emad Tajkhorshid},
  booktitle={eLife},
  year={2017}
}
From bacteria to mammals, different phospholipid species are segregated between the inner and outer leaflets of the plasma membrane by ATP-dependent lipid transporters. Disruption of this asymmetry by ATP-independent phospholipid scrambling is important in cellular signaling, but its mechanism remains incompletely understood. Using MD simulations coupled with experimental assays, we show that the surface hydrophilic transmembrane cavity exposed to the lipid bilayer on the fungal scramblase… CONTINUE READING
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