Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.

@article{BarnettNorris2005LipidsLR,
  title={Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.},
  author={Judy Barnett-Norris and Diane L. Lynch and Patricia H. Reggio},
  journal={Life sciences},
  year={2005},
  volume={77 14},
  pages={1625-39}
}
Scientific views of cell membrane organization are presently changing. Rather than serving only as the medium through which membrane proteins diffuse, lipid bilayers have now been shown to form compartmentalized domains with different biophysical properties (rafts/caveolae). For membrane proteins such as the G protein coupled receptors (GPCRs), a raft domain provides a platform for the assembly of signaling complexes and prevents cross-talk between pathways. Lipid composition also has a strong… CONTINUE READING
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