Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite

Abstract

Toxic effects of a detriazinyl metabolite of almitrine (DTMA) were evaluated in rats and on cultured rat macrophages. In rats daily treated with DTMA for 16 weeks, spastic gaits with heel-lifting appeared, and lamellated and/or crystalloid bodies formed in sensory neurons, satellite cells, Schwann cells, and vascular endothelial cells of the dorsal root ganglia. The lysosomal lamellated bodies, which were not induced by almitrine, were produced also in cultured rat macrophages exposed to over 1 ξ 10−5 M DTMA.

DOI: 10.1007/s002040050189

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Cite this paper

@article{Yamanaka1995LipidosisOT, title={Lipidosis of the dorsal root ganglia in rats treated with an almitrine metabolite}, author={Yoshihiro Yamanaka and Emiko Sakamoto and Yasuji Sakuma and Hiroshi Uno and Tamotsu Koyama and Yoshihiro Izawa and Kosaku Fujiwara}, journal={Archives of Toxicology}, year={1995}, volume={69}, pages={391-396} }