Lipidomics for clinical diagnosis: Dye-Assisted Laser Desorption/Ionization (DALDI) method for lipids detection in MALDI mass spectrometry imaging.

@article{Arafah2014LipidomicsFC,
  title={Lipidomics for clinical diagnosis: Dye-Assisted Laser Desorption/Ionization (DALDI) method for lipids detection in MALDI mass spectrometry imaging.},
  author={Karim Arafah and R{\'e}mi Longuesp{\'e}e and Annie Desmons and Olivier Kerdraon and Isabelle Fournier and Michel Salzet},
  journal={Omics : a journal of integrative biology},
  year={2014},
  volume={18 8},
  pages={487-98}
}
Lipid-based biomarkers for research and diagnosis are rapidly emerging to unpack the basis of person-to-person and population variations in disease susceptibility, drug and nutritional responses, to name but a few. Hence, with the advent of MALDI Mass Spectrometry Imaging, lipids have begun to be investigated intensively. However, lipids are highly mobile during tissue preparation, and are soluble in the solvent used for matrix preparation or in the fixing fluid such as formalin, resulting in… CONTINUE READING