Lipidome and proteome map of myelin membranes.

  title={Lipidome and proteome map of myelin membranes.},
  author={Gopakumar M. Gopalakrishnan and Anshul Awasthi and Wiam Belkaid and Omar de Faria and Dalinda Liazoghli and David R. Colman and Ajit Singh Dhaunchak},
  journal={Journal of neuroscience research},
  volume={91 3},
To understand the molecular anatomy of myelin membranes, we performed a large-scale, liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS)-based lipidome and proteome screen on freshly purified human and murine myelin fractions. We identified more than 700 lipid moieties and above 1,000 proteins in the two species, including 284 common lipids and 257 common proteins. This study establishes the first comprehensive map of myelin membrane components in human and mice. Although this… CONTINUE READING