Lipidic vector systems for gene transfer.

@article{Lee1997LipidicVS,
  title={Lipidic vector systems for gene transfer.},
  author={Robert J. Lee and Lan Huang},
  journal={Critical reviews in therapeutic drug carrier systems},
  year={1997},
  volume={14 2},
  pages={
          173-206
        }
}

• Robert J. Lee, Lan Huang
• Published in
  Critical reviews in…
  1997
• DOI:10.1615/critrevtherdrugcarriersyst.v14.i2.30

Clinical application of gene therapy depends on the development of suitable gene transfer vehicles (vectors). Although generally not as efficient as viral vectors, nonviral systems such as lipidic vectors have the potential advantages of being less toxic, nonrestrictive in cargo DNA size, potentially targetable, and easy to produce in relatively large amounts. More important, lipidic vectors generally lack immunogenicity, allowing repeated in vivo transfection using the same vector. In this… CONTINUE READING

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