Lipidated peptidomimetics with improved antimicrobial activity.


We report a series of lipidated α-AApeptides that mimic the structure and function of natural antimicrobial lipopeptides. Several short lipidated α-AApeptides show broad-spectrum activity against a range of clinically related Gram-positive and Gram-negative bacteria as well as fungus. Their antimicrobial activity and selectivity are comparable or even superior to the clinical candidate pexiganan as well as previously reported linear α-AApeptides. The further development of lipidated α-AApeptides will lead to a new class of antibiotics to combat drug resistance.

DOI: 10.1021/ml3001215
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@article{Hu2012LipidatedPW, title={Lipidated peptidomimetics with improved antimicrobial activity.}, author={Yaogang Hu and Mohamad Nassir Amin and Shruti Padhee and Rongsheng E Wang and Qiao Qiao and Ge Bai and Yaqong Li and Archana Mathew and Chuanhai Cao and Jianfeng Cai}, journal={ACS medicinal chemistry letters}, year={2012}, volume={3 8}, pages={683-6} }