Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation.

  title={Lipidated connexin mimetic peptides potently inhibit gap junction-mediated Ca2+-wave propagation.},
  author={Maura L Cotter and S. Boitano and J. V{\'a}gner and J. Burt},
  journal={American journal of physiology. Cell physiology},
  volume={315 2},
  • Maura L Cotter, S. Boitano, +1 author J. Burt
  • Published 2018
  • Chemistry, Medicine
  • American journal of physiology. Cell physiology
  • Connexin (Cx) mimetic peptides (e.g., Gap27: SRPTEKTIFII; Peptide5: VDCFLSRPTEKT) reversibly inhibit hemichannel (HCh) and gap junction channel (GJCh) function in a concentration- and time-dependent manner (HCh: ~5 µM, <1 h; GJCh: ~100 µM, > 1 h). We hypothesized that addition of a hexadecyl tail to SRPTEKT (SRPTEKT- Hdc) would improve its ability to concentrate in the plasma membrane and consequently increase its inhibitory efficacy. We show that SRPTEKT- Hdc inhibited intercellular Ca2+-wave… CONTINUE READING
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