Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance.

@article{Aouadi2014LipidSB,
  title={Lipid storage by adipose tissue macrophages regulates systemic glucose tolerance.},
  author={Myriam Aouadi and Pranitha Vangala and Joseph C. Yawe and Michaela Tencerova and Sarah M. C. Nicoloro and Joshua Cohen and Yuefei Shen and M. Czech},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 4},
  pages={E374-83}
}
Proinflammatory pathways in adipose tissue macrophages (ATMs) can impair glucose tolerance in obesity, but ATMs may also be beneficial as repositories for excess lipid that adipocytes are unable to store. To test this hypothesis, we selectively targeted visceral ATMs in obese mice with siRNA against lipoprotein lipase (LPL), leaving macrophages within other organs unaffected. Selective silencing of ATM LPL decreased foam cell formation in visceral adipose tissue of obese mice, consistent with a… CONTINUE READING

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