Lipid second messengers and cell signaling in vascular wall

  title={Lipid second messengers and cell signaling in vascular wall},
  author={Nina V. Prokazova and Nelya N. Samovilova and Natalia K Golovanova and E V Gracheva and A. A. Korotaeva and Elena R. Andreeva},
  journal={Biochemistry (Moscow)},
Agonists of cellular receptors, such as receptor tyrosine kinases, G protein-coupled receptors, cytokine receptors, etc., activate phospholipases (Cγ, Cβ, A2, D), sphingomyelinase, and phosphatidylinositol-3-kinase. This produces active lipid metabolites, some of which are second messengers: inositol trisphosphate, diacylglycerides, ceramide, and phosphatidylinositol 3,4,5-trisphosphate. These universal mechanisms are involved in signal transduction to maintain blood vessel functions… 
Role of the phosphoinositide signal transduction pathway in the endometrium
The role of PI, the expression of selected PI-PLC enzymes and the crosstalk with further signaling systems in the endometrium will be discussed.
Mechanical Cyclic Strain Induces Ceramide Generation in Endothelial Cells
It is hypothesized that mechanical, uniaxial cyclic strain results in an increase in intracellular ceramide in vascular endothelial cells, which participates in signaling necessary to propagate mechanotransduction responses, potentially contributing to early events in the formation of atherosclerotic lesions.
Lipid Metabolism and Lipidomics Applications in Cancer Research.
Multidimensional mass spectrometry-based shotgun lipidomics (MDMS-SL) uses direct infusion to avoid difficulties from alterations in concentration, chromatographic anomalies, and ion-pairing alterations to improve resolution and achieve rapid and accurate qualitative and quantitative analysis.
A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction
It is found that aging leads to a significant increase in total mitochondrial ceramides and nSMase status, and the findings suggest that mGSH status plays a critical role in the maintenance of ceramide levels within mitochondria.
Age-Associated Lipidome Changes in Metaphase II Mouse Oocytes
The data reveal that several classes of phospholipids are affected in aged oocytes, suggesting that the integrity of plasma membrane is associated with maintaining fertilization and developmental potential of mouse oocytes.
Visualization of biomolecules in the eyestalk of the blue swimming crab, Portunus pelagicus, by imaging mass spectrometry using the atmospheric‐pressure mass microscope
We have developed an imaging mass spectrometer ― the atmospheric-pressure mass microscope ― with high spatial resolution, which is composed of an atmospheric pressure ion-source chamber for


Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells.
Alterations of these highly regulated signaling pathways in vascular smooth cells may be pivotal in structural and functional abnormalities that underlie vascular pathological processes in cardiovascular diseases such as hypertension, atherosclerosis, and post-interventional restenosis.
Physiological and pathophysiological aspects of ceramide.
  • E. Gulbins, P. Li
  • Biology, Medicine
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2006
Ceramide-enriched membrane platforms do not seem to be part of a specific signaling pathway but may facilitate and amplify the specific signaling elicited by the cognate stimulus, which may enable them to be critically involved in the induction of apoptosis by death receptors and stress stimuli, bacterial and viral infections of mammalian cells, and the regulation of cardiovascular functions.
Integrin-dependent control of inositol lipid synthesis in vascular endothelial cells and smooth muscle cells.
The data suggest that ECM binding may increase PIP2 mass in vascular cells by clustering cell surface integrin receptors and activating cytoskeletal-associated PIP kinases locally within the focal adhesion complex.
Sphingolipid metabolites differentially regulate extracellular signal-regulated kinase and stress-activated protein kinase cascades.
In concurrent experiments utilizing rat glomerular mesangial cells, it is demonstrated that growth factors or sphingosine activate ERK but not SAPK, and ceramide can suppress growth factor- or sphedosine-induced ERK activation as well as proliferation.
Modulation of Protein Kinase Activity and Gene Expression by Reactive Oxygen Species and Their Role in Vascular Physiology and Pathophysiology
Reactive oxygen species participate in vascular smooth muscle cell growth and migration; modulation of endothelial function, including endothelium-dependent relaxation and expression of a proinflammatory phenotype; and modification of the extracellular matrix.
Role of ceramide in activation of stress-associated MAP kinases by minimally modified LDL in vascular smooth muscle cells.
Ceramide, the hydrolysis product of sphingomyelin, seems to be a key mediator as it mimics mmLDL by inducing activation of the same signaling components and is very likely to be primarily responsible for triggering intracellular signal transduction in SMC after exposure tommLDL via formation of ceramide by an autocatalytic mechanism.
Phosphoinositide and calcium signalling responses in smooth muscle cells: comparison between lipoproteins, Ang II, and PDGF.
It is proposed that LDL and HDL3 stimulate signal transduction in VSMC via mechanisms analogous to those of Ca(2+)-mobilizing hormones.
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The recent findings that suggest the existence of novel signaling mechanisms whereby AngII mediates processes, such as activation of receptor or non-receptor tyrosine kinases and ROS, as well as cross-talk between insulin and NO signal transduction in VSMCs and ECs are focused on.
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Sphingomyelin metabolites in vascular cell signaling and atherogenesis.
The potential implication of the sphingomyelin/ceramide cycle in vascular cell signaling related to atherosclerosis, and more generally the role of sphingolipids in the events observed during the atherosclerotic process are reviewed.