Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.

@article{Bern2011LipidRA,
  title={Lipid resuscitation: a life-saving antidote for local anesthetic toxicity.},
  author={Sarah Bern and Belinda Akpa and Ilin Kuo and Guy Weinberg},
  journal={Current pharmaceutical biotechnology},
  year={2011},
  volume={12 2},
  pages={313-9}
}
Local anesthetic toxicity is a rare, but potentially lethal, complication of regional anesthesia that cannot be prevented by any single measure. It is associated with CNS excitation and can lead to refractory cardiac dysfunction and collapse. The development of lipid emulsion for the treatment of anesthetic-induced toxicity resulted from a set of observations during a study on the potent, lipophilic drug bupivacaine and its associated clinical risk of intransigent cardiac toxicity in otherwise… CONTINUE READING