Lipid rescue resuscitation from local anaesthetic cardiac toxicity.

  title={Lipid rescue resuscitation from local anaesthetic cardiac toxicity.},
  author={Guy L. Weinberg},
  journal={Toxicological reviews},
  volume={25 3},
Systemic local anaesthetic toxicity is a rare but potentially fatal complication of regional anaesthesia. This toxicity is due to inhibition of ionotropic and metabotropic cell signal systems and possibly mitochondrial metabolism. It is associated with CNS excitation and, in the extreme, refractory cardiac dysfunction and circulatory collapse. Infusion of lipid emulsion has been shown in animal models to reliably reverse otherwise intractable cardiac toxicity and the mechanism of lipid rescue… CONTINUE READING