Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

@inproceedings{Faulkner2013LipidregulatedDO,
  title={Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells},
  author={Rebecca A. Faulkner and Andrew D Nguyen and Youngah Jo and Russell A. DeBose-Boyd},
  booktitle={Journal of lipid research},
  year={2013}
}
In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD). The ERAD of reductase slows a rate-limiting step in cholesterol synthesis and results from sterol-induced binding of its membrane domain to Insig-1 and the highly related Insig-2 protein. Insig binding bridges reductase to ubiquitin ligases that facilitate its ubiquitination, thereby marking the… CONTINUE READING