Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells.

@article{Segall1999LipidRT,
  title={Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells.},
  author={Laura Segall and Nathalie Lameloise and Françoise Assimacopoulos-Jeannet and Enrique Roche and Pamela Corkey and St{\'e}phane Thumelin and Barbara E Corkey and Marc Prentki},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1999},
  volume={277 3},
  pages={E521-E528}
}
A comprehensive metabolic study was carried out to understand how chronic exposure of pancreatic β-cells to fatty acids causes high basal secretion and impairs glucose-induced insulin release. INS-1 β-cells were exposed to 0.4 mM oleate for 3 days and subsequently incubated at 5 or 25 mM glucose, after which various parameters were measured. Chronic oleate promoted triglyceride deposition, increased fatty acid oxidation and esterification, and reduced malonyl-CoA at low glucose in association… CONTINUE READING