Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization.

@article{Stoddart2002LipidRU,
  title={Lipid rafts unite signaling cascades with clathrin to regulate BCR internalization.},
  author={Angela Stoddart and Michelle L. Dykstra and Bruce K. Brown and Wenxia Song and Susan K Pierce and Frances M. Brodsky},
  journal={Immunity},
  year={2002},
  volume={17 4},
  pages={451-62}
}
A major function of the B cell is the internalization of antigen through the BCR for processing and presentation to T cells. While there is evidence suggesting that lipid raft signaling may regulate internalization, the molecular machinery coordinating these two processes remains to be defined. Here we present a link between the B cell signaling and internalization machinery and show that Src-family kinase activity is required for inducible clathrin heavy chain phosphorylation, BCR… CONTINUE READING