Lipid rafts modulate the activation but not the maintenance of store-operated Ca(2+) entry.

@article{Galn2010LipidRM,
  title={Lipid rafts modulate the activation but not the maintenance of store-operated Ca(2+) entry.},
  author={Carmen Gal{\'a}n and Geoffrey E. Woodard and Natalia Dionisio and Gin{\'e}s M Salido and Juan Antonio Rosado},
  journal={Biochimica et biophysica acta},
  year={2010},
  volume={1803 9},
  pages={1083-93}
}
Different studies have reported that proteins involved in Ca(2+) entry are localized in discrete plasma membrane domains known as lipid rafts, which have been suggested to support store-operated Ca(2+) entry by facilitating STIM1 clustering in endoplasmic reticulum-plasma membrane junctions as well as the interaction of STIM1 with TRPC1. Here we report that treatment of HEK293 cells with thapsigargin (TG) results in the activation of Ca(2+) entry with two components, an early, La(3+)-sensitive… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…