Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model

@inproceedings{Gnanasekaran2011LipidRC,
  title={Lipid rafts control P2X3 receptor distribution and function in trigeminal sensory neurons of a transgenic migraine mouse model},
  author={Aswini Gnanasekaran and Mayya Sundukova and Arn M. J. M. van den Maagdenberg and E. Fabbretti and Andrea Nistri},
  booktitle={Molecular pain},
  year={2011}
}
BACKGROUND A genetic knock-in mouse model expressing the R192Q mutation of the α1-subunit of the Ca(V)2.1 channels frequently found in patients with familial hemiplegic migraine shows functional upregulation of ATP-sensitive P2X3 receptors of trigeminal sensory neurons that transduce nociceptive inputs to the brainstem. In an attempt to understand the basic mechanisms linked to the upregulation of P2X3 receptor activity, we investigated the influence of the lipid domain of these trigeminal… CONTINUE READING

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